From experience with a friends truck 97 Chevrolet extended cab, it did not like subs up with port up on the side. It did very well with subs up port forward in the center on the bottom.
(2015 MECA Street 3 World Champion)
2004 Dodge Ram Single Cab 1500
3 Incriminator Audio Judge 15s
3.25:1 Ratio 4th Order Blowthrough
1 x AA 9.0 TFHE, 2 x AA 150.4
4 X Crossfire XS-M8's, 2 x PRV Tweets